3/14/2024 0 Comments Sage act pro 2013 sp update![]() Trials with antibiotics have not reduced recurrent cardiovascular events, nor have vaccination strategies yet achieved clinical translation. Infectious processes and products of the endogenous microbiome might also modulate atherosclerosis and its complications either directly or indirectly by eliciting local and systemic responses that potentiate disease expression. ![]() The factors that incite innate and adaptive immune responses implicated in atherogenesis and in lesion complication include traditional risk factors such as protein and lipid components of native and modified low-density lipoprotein (LDL), angiotensin II, smoking, visceral adipose tissue, and dysmetabolism. Observations on human and experimental atherosclerosis, biomarker studies, and now a large-scale clinical trial support the operation of immune and inflammatory pathways in this disease.
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